Polyethylene Oxide 1M CAS 25322-68-3 Binder for Pharmaceutical Tablet Direct Compression
Polyethylene Oxide MW 1,000,000 (PEO 1M, CAS 25322-68-3) is linear pharmaceutical-grade water-soluble polyether polymer. It is a multifunctional excipient suitable for direct compression tableting process. The powder possesses good free-flow property and powerful binding capacity without wet granulation. It effectively enhances tablet mechanical strength and minimizes tablet cracking during compression. After contact with aqueous medium, hydrated polymer chains form gel network to control API di
Product Overview
Polyethylene Oxide MW 1,000,000 (CAS 25322-68-3) is pharma-grade ultra-high molecular weight PEO specially developed for direct compression formulation. Medium molecular weight PEO has insufficient binding strength; extra-high molecular weight grades may cause excessive swelling and uncontrollable dissolution rate. This 1M grade balances compressibility, binding performance and matrix sustained-release capability. It can be directly dry blended with APIs and other excipients, simplifying manufacturing by removing wet granulation steps. During compression, polymer particles bond powder mixture tightly to produce intact tablets. Meanwhile, the hydrated gel layer enables adjustable sustained release for long-acting pharmaceutical preparations.
Key Features
- Molecular Weight: 1,000,000, CAS 25322-68-3, white free-flowing fine powder
- Pharmaceutical grade, meets relevant pharmacopoeia specification requirements
- Excellent flowability and dry binding property, ideal for direct compression
- Improve tablet hardness, reduce capping, lamination and friability
- Form hydrophilic gel matrix to realize sustained drug release
- Nonionic structure, low chemical interaction with most active pharmaceutical ingredients
- Good thermal stability, compatible with hot melt extrusion and solid formulation processes
Main Applications
- Dry binder for direct compression immediate-release tablets
- Sustained-release matrix material for oral prolonged-action tablets
- Functional excipient for mucoadhesive tablets and osmotic pump formulations
- Film-forming and binding additive for oral thin film preparations
Usage Guidance
Uniformly dry blend PEO powder with API, filler and lubricants before tableting. Typical dosage: 5% ~35% of total tablet formula weight. Adjust addition amount according to target tablet hardness and dissolution profile. Conduct compression test and dissolution evaluation to confirm optimal formula before formal production. Avoid long-term exposure to high temperature and air to prevent polymer degradation.
Storage & Package
Hermetically sealed packaging. Store in cool, dry, low-oxygen warehouse, avoid moisture absorption, high temperature and direct sunlight. Standard package: 25kg aluminum foil lined kraft bag. Shelf life: 12 months under proper sealed storage.
Service Support
Pharma grade test samples available for formula research. Stable bulk supply. We can provide COA, TDS and supporting documents for registration. Welcome to inquire factory price and technical guidance for tablet formulation.
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