PEO 4M (Polyethylene Oxide MW 4,000,000, CAS 25322-68-3) is linear pharmaceutical-grade ultra-high molecular weight water-soluble polyether polymer. It serves as a key matrix-forming excipient for sustained-release tablets. When exposed to gastrointestinal fluid, the polymer hydrates and creates a viscous hydrophilic gel barrier, controlling the diffusion speed of active ingredients to achieve long-lasting drug release. It features good powder flowability and compression performance, compatible

Product Detail

Product Overview

Polyethylene Oxide MW 4,000,000 (CAS 25322-68-3) is pharma-grade high molecular weight PEO developed for sustained release oral formulations. Lower molecular weight PEO cannot build durable gel barriers; extra-high molecular variants may lead to over-swelling and uncontrollable release profiles. This 4M grade achieves ideal balance of compressibility, gel strength and drug release modulation capacity.

It can be processed by direct compression or wet granulation. After tablet administration, surface hydration generates a continuous gel matrix. The gel layer gradually erodes, steadily slowing API diffusion to maintain stable plasma drug concentration and reduce frequent administration.

Key Features

Molecular Weight: 4,000,000, CAS 25322-68-3, white free-flowing fine powder
Pharmaceutical grade, meets relevant pharmacopoeia specifications
Form robust hydrophilic gel matrix to realize adjustable sustained drug release
Great flowability and compression property, suitable for direct compression technology
Minimal chemical interaction with most active pharmaceutical ingredients
Excellent thermal stability, compatible with hot melt extrusion processes
Can be combined with other excipients to customize targeted dissolution curves

Main Applications

Hydrophilic matrix material for oral sustained-release tablets
Functional polymer for osmotic pump controlled-release tablet systems
Mucoadhesive excipient for buccal and gastrointestinal mucoadhesive preparations
Binding and film-forming additive for slow-release oral thin films

Usage Guidance

Can be dry blended with APIs, fillers and lubricants for direct compression, or used in wet granulation process. Typical dosage range: 8% ~40% of total tablet weight. Adjust proportion according to target dissolution requirement. Carry out compression test and in-vitro dissolution evaluation to confirm optimal formula. Avoid long-term exposure to high temperature and air to prevent polymer degradation.

Storage & Package

Hermetically sealed packaging. Store in cool, dry warehouse away from high temperature, oxygen and direct sunlight. Standard package: 25kg aluminum foil lined kraft bag. Shelf life: 12 months under sealed proper storage.

Service Support

Pharmaceutical grade test samples available for formula development. Stable bulk supply. We can provide supporting documents including COA, TDS for drug registration. Welcome to inquire factory price and formulation technical guidance.

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PEO 4M CAS 25322-68-3 Controlled Release Matrix for Pharmaceutical Tablets

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Jishengya Technology

Shenzhen Jishengya Technology Co., Ltd. is located in Shenzhen, a special economic zone, and is a comprehensive technology enterprise integrating independent R&D, production and sales.