PEO NF Grade CAS 25322-68-3 Controlled Release Matrix for Sustained Release Drugs
NF Grade Polyethylene Oxide (PEO, CAS 25322-68-3) is high purity linear water-soluble polyether polymer that meets National Formulary (NF) specifications. When used in sustained release formulations, PEO hydrates and creates a viscous gel barrier on tablet surface after contacting gastrointestinal fluid. The gel matrix controls the diffusion of active ingredients to achieve zero-order or predictable sustained drug release. With consistent molecular weight distribution and low impurity levels, th
Product Overview
NF Grade Polyethylene Oxide CAS 25322-68-3 is professional hydrophilic matrix excipient designed for sustained and controlled release oral drugs. Many conventional matrix materials face unstable release rate and batch fluctuation issues. This NF grade PEO features strict molecular weight control and high purity. It forms uniform hydrated gel matrix, provides predictable long-term drug release, simplifies formulation development and improves the consistency of finished sustained-release tablets.
Key Features
- CAS Number: 25322-68-3, NF Grade, Appearance: White free-flowing fine powder
- Complies with National Formulary (NF) specifications for pharmaceutical excipients
- Forms uniform hydrated gel layer to achieve stable sustained/controlled drug release
- Supports zero-order release kinetics for numerous active pharmaceutical ingredients
- Excellent compatibility with most APIs, fillers and other tablet excipients
- Precise molecular weight grades available to customize release profiles
- Low residual impurities, stable physical and chemical properties
- Suitable for direct compression and wet granulation manufacturing processes
Main Applications
- Hydrophilic matrix material for sustained release oral tablets
- Controlled release excipient for extended-release solid pharmaceutical formulations
- Rate-controlling polymer for once-daily oral drug delivery systems
- Research raw material for new sustained-release pharmaceutical development
Usage Guidance
Suitable for direct compression or incorporated during wet granulation. The dosage and molecular weight selection depend on target release profile. Preformulation compatibility and dissolution tests are strongly recommended. Avoid intense high-shear mixing to prevent polymer chain degradation. All manufacturing operations should comply with GMP standards.
Storage & Package
Keep tightly sealed. Store in clean, cool, dry warehouse, protect from humidity, heat and direct sunlight. Standard package: 25kg pharmaceutical grade kraft bag with food-grade inner PE liner. Shelf life: 12 months under sealed proper storage.
Service Support
Formulation trial samples available. We can provide COA, specification documents. Stable bulk supply. Welcome to contact for factory quotation.
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